Definitely not open 24 hours do not believe that internet, closed at 5 to 7 at least gate closed doors open no one inside

24 hour smoke shop that carries everything (almost everything). Great selection, decent prices & friendly staff who are polite and patient. Bought things here at 3am that have replaced broken bongs, allowing the fun weekend parties to continue. Def recommend. Prices are fair

Second time here, second time regretting it. They brag about being “24 hours,” yet at 7:15 AM the door is unlocked and open, the gate is shut, and not a single employee is anywhere to be found. How do you call yourself 24/7 when you can’t make it past sunrise? This isn’t a business—it’s a guessing game. If you need reliability, go literally anywhere else.

Out of town so I rely on my navigation's info and it states this place OPEN 24 HRS. It's 5:31 am. Neon sign says OPEN, door is OPEN wide, and all the lights are on. It appears to be what it says but with no one inside and a locked gate around the entire storefront, it clearly is NOT OPEN. It is most definitely CLOSED. Maybe if they changed the name to Schrödinger's Smoke & Vape they could achieve both.

City Smoke & Vape is a prominent corner shop in the Mission District, widely known for being one of the few specialty smoke shops in San Francisco that stays open 24 hours a day. It serves as a reliable local hub for both traditional smokers and vape enthusiasts, offering a "one-stop-shop" experience without the need to travel into more crowded areas like the Tenderloin. ​Diverse Inventory: The shop is recognized for its extensive selection of glass pipes, hookahs, and accessories, alongside a dedicated section for hip-hop-inspired apparel and streetwear. ​Service & Expertise: Visitors frequently highlight the "wonderful customer service," describing the staff as informative, patient, and willing to troubleshoot device issues or help select the right products. ​24/7 Convenience: Its round-the-clock operation makes it a primary destination for late-night needs, providing a clean and well-organized environment even during the early morning hours. ​Vape Selection: Despite strict city-wide regulations on flavored nicotine, the shop maintains a solid stock of permitted tobacco-flavored products, coils, and hardware, with reviewers often calling it a "vape gem" for its depth of hardware options. ​While the shop generally maintains high standards, some patrons have noted that prices can be slightly higher than online retailers—typical for a physical storefront in San Francisco—and a few reviews suggest double-checking product expiration dates on any pre-packaged goods. Overall, City Smoke & Vape is highly recommended for its friendly neighborhood vibe and unmatched accessibility in the city.